LGD4033 (Ligandrol) Driada Medical

LGD4033 (Ligandrol)

About Ligandrol

• One of the most effective SARMs for increasing muscle mass and strength. Ideal for bulking cycles.
• Significantly suppresses testosterone levels compared to other SARMs.
• It can cause fluid retention in the muscles, resulting in a slightly edematous appearance.
• Like other SARMs, it can affect the lipid profile and increase liver enzymes.

What is Ligandrol?

Ligandrol, also known as LGD4033, is a widely used SARM that has undergone several human clinical trials and is currently in Phase 2 clinical trials. Initially developed by Ligand Pharmaceuticals for muscle-wasting conditions such as cancer or AIDS, Ligandrol is a second-generation SARM that offers improvements over previous versions such as S4. In terms of research, Ligandrol is the second most studied SARM after Ostarine.

Ligandrol is highly regarded for its muscle-building properties, although it also exhibits the most pronounced suppression of natural testosterone production among SARMs. However, its extended half-life of 24–36 hours allows for once-daily administration, leading to increased bloodstream concentrations over time.

Effects

• Significant increase in muscle mass, potentially accompanied by mild fluid retention (as reported by users on Reddit).
• Significant improvement in strength levels, making Ligandrol one of the most effective SARMs in this regard.
• Improved bone mineral density.
• Reduction of SHBG (Sex Hormone Binding Globulin) levels. Ligandrol reduces SHBG, a protein that binds to testosterone, thereby increasing the amount of free testosterone available for use.

Testosterone Suppression

Ligandrol is known to cause more severe testosterone suppression than other SARMs. As a result, users may experience symptoms such as reduced libido and other signs of low testosterone, which usually occur around the fourth week. The severity of these symptoms depends on individual baseline testosterone levels and sensitivity. It’s important to note that LGD4033 exhibits dose-dependent testosterone suppression. In one scientific study, hormone levels returned to normal by day 56 after a 21-day Ligandrol cycle, underscoring the need for post-cycle therapy (PTC).

To mitigate the decrease in blood testosterone, it is advisable to include selective estrogen receptor modulators (SERMs) such as clomiphene or tamoxifen, or testosterone/gonadotropin during the Ligandrol cycle to maintain adequate testosterone levels.

Impact on the Liver

Ligandrol use may lead to elevated liver enzymes, particularly ALT and AST. To counteract this potential side effect, supplements such as NAC (N-acetylcysteine) in the dosage range of 600–1200 mg, TUDCA (tauroursodeoxycholic acid) at 500 mg, and ALA (alpha-lipoic acid) at 500 mg may provide protection.

Lipid Profile Changes

Although SARMs have a less significant impact on cholesterol levels than anabolic steroids, they can still affect your lipid profile. Typically, SARMs reduce HDL (good cholesterol) levels and increase LDL (bad cholesterol). Regular blood tests to monitor your cholesterol levels during a Ligandrol cycle are recommended.

Half-life

The half-life of Ligandrol is approximately 24-36 hours.

Dosage

• Minimum effective dosage (beginner): 5-10 mg
• Average dosage: 10-30 mg
• Maximum recommended dosage: 40 mg
• Women: 5 mg